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This suggests a potential role of heavy metals in Alzheimer’s disease, but it is not yet clear whether they interfere in the development or the progression of the disease. Human epidemiological studies have showed that circulating levels of certain heavy metals are higher in patients with Alzheimer’s disease than in control patients ( Fathabadi et al. Our hypothesis is that environmental pollutants may corrupt APP metabolism or the A β aggregation process, which may lead to the onset or aggravation of Alzheimer’s disease. The causes leading to these deregulations have not yet been clearly identified. 2014) involved in the A β clearance pathways are major events reinforcing the disease. 2007), and/or receptors such as the low-density lipoprotein receptor-related protein 1 (LRP1) ( Kang et al. Impairments of enzymes such as insulin degrading enzyme (IDE) ( Miners et al. 2001) and γ -secretases ( Carroll and Li 2016) (for a review on APP processing, see O’Brien and Wong 2011). A β peptides are produced by the sequential enzymatic processing of the amyloid precursor protein (APP) by the β - (BACE1) ( Cai et al. One of the features of Alzheimer’s disease is the accumulation and aggregation of amyloid- β peptides ( A β ) into amyloid plaques ( Iwatsubo et al. Indeed, projection studies of the incidence of Alzheimer’s disease between 20 have indicated that delaying the onset of Alzheimer’s disease by 1, 2, or 5 y could decrease its prevalence by about 10%, 20%, and 50%, respectively ( Mura et al. However, identifying environmental risk factors may represent an alternative strategy to reduce the number of cases. The etiology of Alzheimer’s disease has not yet been clarified, which may explain the lack of effective treatments. Know Moreīridging the Digital Divide through EdTech Capacity-building in Communities in IndiaĮfforts toward government and community capacity building are more important now than ever, to ensure that the progress made with digital interventions during the pandemic is leveraged effectively going forward.Alzheimer’s disease is the most common form of dementia in elderly people and currently afflicts 50 million people worldwide, and this number is expected to double in the coming generation ( OECD 2018).
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Selected under the Adult Learning track, YouthNet, a remote learning program aimed upskilling learners (aged 14-25), is one of the scalable educational tools eligible to share the award prize of $4 million. Pratham – Shah PraDigi Innovation Centre is selected as one of the winners of the Learning Engineering Tools Competition 2021-22 In Botswana, India and Zambia students are getting catch-up classes of a type pioneered by Pratham Know More Know MoreĬovid learning loss has been a global disaster The Plastic STORI is a step in the direction of helping children and youth families and communities become aware about the problem of plastic waste management and finding solutions. The Plastic STORI (Plastic study of rural India)